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New treatment destroys head and neck cancer tumors in trial

Combination of drugs causes tumors to vanish in some terminally ill patients, study finds

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New treatment destroys head and neck cancer tumors in trial

A new cancer treatment can wipe out tumours in terminally ill head and neck cancer patients, scientists have discovered.

In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.

One patient, who was expected to die four years ago, told the Guardian of the “amazing” moment nurses called him weeks after he joined the study to say his tumour had “completely disappeared”. The 77-year-old grandfather is now cancer-free and spent last week on a cruise with his wife.

Scientists found the combination of nivolumab and ipilimumab medications led to a reduction in the size of tumours in terminally ill head and neck cancer patients. In some, their cancer vanished altogether, with doctors stunned to find no detectable sign of disease.

Combining the two immunotherapy drugs could prove an effective new weapon against several forms of advanced cancer, experts believe. Results from other trials of the drug combination have previously suggested similar benefits for terminally ill kidney, skin and bowel cancer patients.

As well as boosting the long-term survival chances of patients, scientists said, the immunotherapy treatment also triggered far fewer side-effects compared with the often gruelling nature of “extreme” chemotherapy, which is the standard treatment offered to many patients with advanced cancer.

The results from the phase 3 trial, involving almost 1,000 dying head and neck cancer patients, were early and not statistically significant but were still “clinically meaningful”, the ICR said, with some patients living months or years longer and suffering fewer side effects.

“These are promising results,” Prof Kristian Helin, the ICR chief executive, told the Guardian. “Immunotherapies are kinder, smarter treatments that can bring significant benefits to patients.”

About 12,000 people in the UK are diagnosed with head and neck cancer every year and many will be diagnosed at advanced stages. There is an urgent need for better, kinder treatments for these patients that can keep them alive longer than the current standard of care.

When Barry Ambrose, 77, from Bury St Edmunds, was diagnosed with throat cancer in 2017, he was told that it had already spread to his lungs – and that hospital palliative care was his only option.

But in a turn of events that saved his life, Ambrose was offered the chance to join the new study. “When I was told about the trial … I didn’t hesitate to join – what did I have to lose? It turned out to be a lifeline.

“Although I had to make biweekly trips from Suffolk to the hospital for the treatment, I had virtually no side-effects and was able to carry on as normal doing the things I love: sailing, cycling, and spending time with my family.”

Within about eight weeks of starting the treatment, scans revealed the tumour in his throat had been eradicated.

“When the research nurses called to tell me that, after two months, the tumour in my throat had completely disappeared, it was an amazing moment,” said Ambrose. “While there was still disease in my lungs at that point, the effect was staggering.”

He later underwent chemotherapy, followed by surgery. He currently has no evidence of disease.

Read more the Guardian

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Biden Vaccine Mandate for Contractors Blocked Nationwide

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Biden Vaccine Mandate for Contractors Blocked Nationwide
  • Mandate one of a set of Biden vaccine initiatives
  • States say contractor requirement violates Constitution

The Biden administration’s mandate for federal contractors’ employees to be vaccinated will be halted nationwide, amid a slew of challenges from states that say the president overstepped his authority in requiring the Covid-19 shots.

Led by Georgia, the seven states that challenged the mandate set to take effect on Jan. 4 are likely to succeed in their lawsuits against the administration’s order, U.S. District Court Judge R. Stan Baker of the Southern District of Georgia said in an order issued Tuesday.

The Biden administration mandate applies to roughly a quarter of the U.S. workforce and affects companies that do business with the federal government, including Lockheed Martin Corp., Microsoft Corp., Alphabet Inc.‘s Google, and General Motors Co.

Baker’s order follows a Kentucky federal judge’s grant last week of a preliminary injunction in a lawsuit involving Kentucky, Tennessee, and Ohio. Baker echoed what his Kentucky counterpart said, that blocking the mandate didn’t indicate that the vaccine wouldn’t be effective to stopping the spread of Covid-19, but rather that Biden didn’t have the power to issue such an executive order.

Representatives from Georgia universities testified during an injunction hearing earlier this month, arguing that implementation of the mandate would be expensive, onerous, and cost them valuable employees who haven’t yet presented proof of vaccination. Those schools receive millions from the federal government.

The court found that the states could likely prove that Congress didn’t clearly authorize the president to issue the mandate, and that it “goes far beyond addressing administrative and management issues in order to promote efficiency and economy in procurement and contracting.” The 2017 nominee of President Donald Trump said, instead, the executive order works as a “regulation of public health.”

Neither the lawyers representing the state coalition nor the U.S. government immediately responded to emailed requests for comment.

Idaho Gov. Brad Little cheered Tuesday’s ruling in a statement. The state is part of the Georgia-led contractor mandate challenge, as well as lawsuits against the Occupational Safety and Hazard Administration’s shot-or-test emergency regulation for large U.S. businesses, and another inoculation rule for healthcare workers.

“Yet another one of President Biden’s vaccine mandates have been temporarily shut down because the states—including Idaho—took a stand against his unprecedented government overreach into Americans’ lives and businesses,” Little said in the statement. “All three mandates are now completely stalled. We will continue to press forward in our fight against the federal government’s bad policies.”

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Men and Boys aged 12 to 29 should no longer take Moderna Vaccine, Says National Advisory Committee on Immunization in Canada

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Luxemburg: People break down barriers of Covid pass checkpoint at Christmas Market

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Luxemburg: People break down barriers of Covid pass checkpoint at Christmas Market

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