A new cancer treatment can wipe out tumours in terminally ill head and neck cancer patients, scientists have discovered.
In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.
One patient, who was expected to die four years ago, told the Guardian of the “amazing” moment nurses called him weeks after he joined the study to say his tumour had “completely disappeared”. The 77-year-old grandfather is now cancer-free and spent last week on a cruise with his wife.
Scientists found the combination of nivolumab and ipilimumab medications led to a reduction in the size of tumours in terminally ill head and neck cancer patients. In some, their cancer vanished altogether, with doctors stunned to find no detectable sign of disease.
Combining the two immunotherapy drugs could prove an effective new weapon against several forms of advanced cancer, experts believe. Results from other trials of the drug combination have previously suggested similar benefits for terminally ill kidney, skin and bowel cancer patients.
As well as boosting the long-term survival chances of patients, scientists said, the immunotherapy treatment also triggered far fewer side-effects compared with the often gruelling nature of “extreme” chemotherapy, which is the standard treatment offered to many patients with advanced cancer.
The results from the phase 3 trial, involving almost 1,000 dying head and neck cancer patients, were early and not statistically significant but were still “clinically meaningful”, the ICR said, with some patients living months or years longer and suffering fewer side effects.
“These are promising results,” Prof Kristian Helin, the ICR chief executive, told the Guardian. “Immunotherapies are kinder, smarter treatments that can bring significant benefits to patients.”
About 12,000 people in the UK are diagnosed with head and neck cancer every year and many will be diagnosed at advanced stages. There is an urgent need for better, kinder treatments for these patients that can keep them alive longer than the current standard of care.
When Barry Ambrose, 77, from Bury St Edmunds, was diagnosed with throat cancer in 2017, he was told that it had already spread to his lungs – and that hospital palliative care was his only option.
But in a turn of events that saved his life, Ambrose was offered the chance to join the new study. “When I was told about the trial … I didn’t hesitate to join – what did I have to lose? It turned out to be a lifeline.
“Although I had to make biweekly trips from Suffolk to the hospital for the treatment, I had virtually no side-effects and was able to carry on as normal doing the things I love: sailing, cycling, and spending time with my family.”
Within about eight weeks of starting the treatment, scans revealed the tumour in his throat had been eradicated.
“When the research nurses called to tell me that, after two months, the tumour in my throat had completely disappeared, it was an amazing moment,” said Ambrose. “While there was still disease in my lungs at that point, the effect was staggering.”
He later underwent chemotherapy, followed by surgery. He currently has no evidence of disease.
Ted Kaczynski, the Unabomber, Has Been Diagnosed with Terminal Cancer
This follows his transfer to a medical facility in December
The new comes from a letter he wrote:
French President Emmanuel Macron Says Someone Who Refuses COVID Vaccine Is ‘Not a Citizen’
French president Macron’s desire to ‘piss off’ unvaccinated individuals triggers outrage
Macron spoke candidly during an interview with French newspaper Le Parisien, during which he said that he wanted to make life difficult for individuals who have not received a COVID-19 vaccine. The French “sanitary pass” has prompted a number of protests and stiff opposition while the country nears 75% full vaccination.
“I really want to piss them off, and we’ll carry on doing this – to the end,” Macron said three months ahead of a presidential election. “I won’t send [unvaccinated people] to prison, so we need to tell them, from 15 January, you will no longer be able to go to the restaurant. You will no longer be able to go for a coffee, you will no longer be able to go to the theatre. You will no longer be able to go to the cinema.”
The French Parliament heard Macron’s comments during a debate over his proposed bill to tighten restrictions for unvaccinated individuals, leading to a swift and strong uproar in response.
His opponents have labeled the comments “unworthy” of a president.
“Even if one doesn’t share their choice, they have broken none of our country’s laws,” Marine Le Pen, Macron’s chief opponent in the upcoming election, told reporters late Tuesday. “He is continuing his policy of division, of pitting the French against one another.”
She later tweeted “A president shouldn’t say that…Emmanuel Macron is unworthy of his office.”
Leftist politician Jean-Luc Melanchon described the remarks as an “astonishing confession,” according to the BBC.
But Macron’s allies have defended the comments, with Stéphane Séjourné, a member of the European Parliament, arguing on Twitter that unvaccinated individuals have “bothered” the French by “forcing the rest of the population to endure restrictions.”
Debate over Macron’s bill continue into Wednesday as opponents still seek to delay its passage. Some of his supporters claimed to have received death threats because they are backing the legislation, The New York Times reported.
Boston Mayor Wu Relentlessly Heckled As New COVID-19 Restrictions Are Announced
Boston unveils the ‘Be Together’ initiative, requiring full vaccination for entry to restaurants, gyms, and sports arenas for anyone 12 and older. In March the mandate will phase-in for younger children.