Pfizer, Merck launch new trials of oral COVID-19 drugs
Sept 1 (Reuters) – Pfizer Inc (PFE.N) and Merck & Co Inc (MRK.N) announced on Wednesday new trials of their experimental oral antiviral drugs for COVID-19 as the race to develop an easy-to-administer treatment for the potentially fatal illness heats up.
Pfizer said its latest mid-to-late-stage trial will enroll 1,140 non-hospitalized adults diagnosed with coronavirus infection who are not at risk of severe illness. Patients in the trial will be given Pfizer’s pill, known as PF-07321332, and a low dose of ritonavir, an older medication widely used in combination treatments for HIV infection.
Pfizer’s drug is designed to block the activity of a key enzyme that is needed for the coronavirus to multiply.
Merck said its new trial will study experimental drug molnupiravir for the prevention of COVID-19 among adults in the same household as someone diagnosed with symptomatic coronavirus infection. Merck and partner Ridgeback Biotherapeutics are already conducting a late-stage trial of the treatment in non-hospitalized patients to see if it reduces the risk of hospitalization or death.
Ted Kaczynski, the Unabomber, Has Been Diagnosed with Terminal Cancer
This follows his transfer to a medical facility in December
The new comes from a letter he wrote:
French President Emmanuel Macron Says Someone Who Refuses COVID Vaccine Is ‘Not a Citizen’
French president Macron’s desire to ‘piss off’ unvaccinated individuals triggers outrage
French President Emmanuel Macron faced significant criticism for his comments claiming that he would like to “piss off” unvaccinated individuals.
Macron spoke candidly during an interview with French newspaper Le Parisien, during which he said that he wanted to make life difficult for individuals who have not received a COVID-19 vaccine. The French “sanitary pass” has prompted a number of protests and stiff opposition while the country nears 75% full vaccination.
“I really want to piss them off, and we’ll carry on doing this – to the end,” Macron said three months ahead of a presidential election. “I won’t send [unvaccinated people] to prison, so we need to tell them, from 15 January, you will no longer be able to go to the restaurant. You will no longer be able to go for a coffee, you will no longer be able to go to the theatre. You will no longer be able to go to the cinema.”
The French Parliament heard Macron’s comments during a debate over his proposed bill to tighten restrictions for unvaccinated individuals, leading to a swift and strong uproar in response.
His opponents have labeled the comments “unworthy” of a president.
“Even if one doesn’t share their choice, they have broken none of our country’s laws,” Marine Le Pen, Macron’s chief opponent in the upcoming election, told reporters late Tuesday. “He is continuing his policy of division, of pitting the French against one another.”
She later tweeted “A president shouldn’t say that…Emmanuel Macron is unworthy of his office.”
Leftist politician Jean-Luc Melanchon described the remarks as an “astonishing confession,” according to the BBC.
But Macron’s allies have defended the comments, with Stéphane Séjourné, a member of the European Parliament, arguing on Twitter that unvaccinated individuals have “bothered” the French by “forcing the rest of the population to endure restrictions.”
Debate over Macron’s bill continue into Wednesday as opponents still seek to delay its passage. Some of his supporters claimed to have received death threats because they are backing the legislation, The New York Times reported.
Boston Mayor Wu Relentlessly Heckled As New COVID-19 Restrictions Are Announced
Boston unveils the ‘Be Together’ initiative, requiring full vaccination for entry to restaurants, gyms, and sports arenas for anyone 12 and older. In March the mandate will phase-in for younger children.